During MI healing, when is scar formation typically completed?

During MI healing, when is scar formation typically completed?

• A. >2 weeks
• B. 0-12 hours
• C. 1-3 days
• D. 3-7 days

Answer: (A)

In MI healing, the scar that replaces necrotic myocardium forms as fibroblasts lay down collagen after inflammatory cells clear the dead tissue. The inflammatory phase and early granulation tissue are over by about one to two weeks, and by around two weeks the infarcted area has become a dense fibrous scar. Remodeling and maturation of this scar continue for weeks to months, but a mature scar is typically in place after more than two weeks. So the timing that best fits “scar formation is completed” is after two weeks or more. Shorter time frames reflect ongoing inflammatory and reparative processes (neutrophil activity in the first days, granulomatous/granulation tissue around the first week), not a fully established scar.

In MI healing, the scar that replaces necrotic myocardium forms as fibroblasts lay down collagen after inflammatory cells clear the dead tissue. The inflammatory phase and early granulation tissue are over by about one to two weeks, and by around two weeks the infarcted area has become a dense fibrous scar. Remodeling and maturation of this scar continue for weeks to months, but a mature scar is typically in place after more than two weeks.

So the timing that best fits “scar formation is completed” is after two weeks or more. Shorter time frames reflect ongoing inflammatory and reparative processes (neutrophil activity in the first days, granulomatous/granulation tissue around the first week), not a fully established scar.